Why does body temp. increase when we have fever?!
Question: Why does body temp!. increase when we have fever!?
Answers:
Increased body temperature is usually induced by some sort of infection, but can be seen with toxin ingestion, malignancy, drug reactions and autoimmune conditions
Fevers are induced by substances called pyrogens which can be endogenous or exogenous!. Although most bacteria have toxins that directly activate the body's central thermoregulatory areas in the brain, they also induce the body to produce endogenous pyrogens as a normal part of the immune response!. When the body responds to an infection it produces substances called cytokines which activates the immune system to fight off the infection
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Fevers are induced by substances called pyrogens which can be endogenous or exogenous!. Although most bacteria have toxins that directly activate the body's central thermoregulatory areas in the brain, they also induce the body to produce endogenous pyrogens as a normal part of the immune response!. When the body responds to an infection it produces substances called cytokines which activates the immune system to fight off the infection
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Example, a patient is infected with speticemia caused by a gram-negative bacteria, the bacteria release endotoxins into the blood stream!.
Phagocytes ingest the endotoxin and stimulates the production of Interleukin 1, an endogenous pyrogen!. IL-1 stimulates the hypothalamus to produce prostaglandins!. Once metabolized, the prostaglandins cause the hypothalamic thermostat to be set at a higher level!.
The increased thermostatic reading sends out signals to the nerves surrounding peripheral blood vessels to contract, thus conserving heat!.
The increased body heat, resulting from vasoconstriction, continues until the temperature of the blood supplying the hypothalamus matches the eleveated thermostat reading!. The thermostat can be reset to the normal temperature when the concentration of endogenous pyrogen decreases!.
Fever attracts WBC's to the site of infection due to the flowing cytokines in the blood stream released by different types of cells, this is called chemotaxis!. Fever, due to the production of IL-1 causes the proliferation, maturation, and activation of lymphocytes in the immunologic response!. Fever also reduces available free plasma iron via transferrin or lactoferrin, which limits the growth of pathogens that require iron for replication and synthesis of toxins!.Www@Answer-Health@Com
Phagocytes ingest the endotoxin and stimulates the production of Interleukin 1, an endogenous pyrogen!. IL-1 stimulates the hypothalamus to produce prostaglandins!. Once metabolized, the prostaglandins cause the hypothalamic thermostat to be set at a higher level!.
The increased thermostatic reading sends out signals to the nerves surrounding peripheral blood vessels to contract, thus conserving heat!.
The increased body heat, resulting from vasoconstriction, continues until the temperature of the blood supplying the hypothalamus matches the eleveated thermostat reading!. The thermostat can be reset to the normal temperature when the concentration of endogenous pyrogen decreases!.
Fever attracts WBC's to the site of infection due to the flowing cytokines in the blood stream released by different types of cells, this is called chemotaxis!. Fever, due to the production of IL-1 causes the proliferation, maturation, and activation of lymphocytes in the immunologic response!. Fever also reduces available free plasma iron via transferrin or lactoferrin, which limits the growth of pathogens that require iron for replication and synthesis of toxins!.Www@Answer-Health@Com
Fever is actually a defense mechanism where the body heats up to try and kill off the invading pathogen by 'cooking' it!. Shivering is also the bodies way of producing heat to kill off invaders!. Temperatures get dangerous when they are too high, like over 104 or 40 degrees celsius because it can cause organ damage and seizures!.Www@Answer-Health@Com
This is due to the fact that our body tries to fight the bacteria and viruses by increasing the heat internally!.Www@Answer-Health@Com
when the defence mechanism in our body starts fighting with foriegn materials then the huge amount of energy released gets converted into heat!.Www@Answer-Health@Com
To put it simply, it makes it harder for bacteria to work cause when temperature increases, the functions of viruses and stuff change!.Www@Answer-Health@Com
when u get fever!.your internal tempurature rise because there is differece we get internal and outer temperature!.Www@Answer-Health@Com
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to justify that we have fever!.Www@Answer-Health@Com
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