Why does oral glucose administration give a greater insulin response than IV?!
Question: Oral glucose administration stimulates hormones in the gastrointestinal tract that in turn stimulates the pancreas to produce more insulin. Because glucose given via IV does not enter the gastrointestinal tract the body misses out on the hormonal response that is activated in the GI tract.
This is part of the way that Byetta works--it mimics some of the incretin hormones that stimulate insulin production and helps increase insulin response with meals.
Answers: Oral glucose administration stimulates hormones in the gastrointestinal tract that in turn stimulates the pancreas to produce more insulin. Because glucose given via IV does not enter the gastrointestinal tract the body misses out on the hormonal response that is activated in the GI tract.
This is part of the way that Byetta works--it mimics some of the incretin hormones that stimulate insulin production and helps increase insulin response with meals.